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YUE-WERN HUANG, Ph.D. Professor Faculty Fellow to Vice Chancellor of
Research and Innovation 400 W. 11th Street
PROFESSIONAL SOCIETY
MEMBERSHIPS
· Society of Toxicology · Society for Biomaterials · American Society of Biochemistry and Molecular Biology · American
Association for the Advancement of Science
(AAAS) EDITORIAL
BOARDS · Current Gene Therapy · MDPI Cells HONORS,
AWARDS, AND FELLOWSHIPS · 2020. Missouri S&T Outstanding Teaching Commendation. · 2010. Missouri S&T Faculty Research Award. · 2008. Missouri S&T Faculty Excellence Award (campus-wide; for outstanding teaching, research and service contributions). · 2008. Keynote Speaker. The 5th Life Science and Biotechnology Forum between Taiwan and China. Presentation title: “Nanotechnology: a Double-edged Sword”. Taipei, Taiwan. · 2006. Best Paper of the Year Award:
selected by the International Journal of Toxicology and presented in the
28th Annual Meeting of the American College of Toxicology in Charlotte,
NC, USA. · 2004. Keynote Speaker. Annual Society of Environmental Toxicology and Chemistry (SETAC) Ozark-Prairie Chapter Meeting (A joint meeting with the SETAC Midwest Chapter). Presentation title: “Searching for possible causes of the population decline in Ozark hellbenders.” La Crosse, WI, USA. · 1998. John Jefferson Davis Fund Summer Scholarship for Research Excellence, Dept. of Zoology of University of Wisconsin. · 1996. Sea Grant Institute Travel Support, University of Wisconsin Sea Grant Institute. · 1994. John Jefferson Davis Fund Travel Award, Dept. of Zoology of University of Wisconsin.
· Evolution and behavior of infectious pathogens in indoor environments · Develop nanocarrier platforms to deliver biologically active molecules in vitro and in vivo for basic science research and biomedical applications · Use bioactive scaffolds to facilitate bone repair and regeneration · Investigate toxicity of nanomaterials to human health risk; in particular, discover physical and chemical properties of nanomaterials that govern molecular mechanisms of nanotoxicity. Findings can be used for QSAR modeling and improvement of safer design of biocompatible nanomaterials · Study effects of environmental estrogens such as pharmaceuticals, phytochemicals, and industrial chemicals on humans and the environment INVENTION DISCLOSURES · 2017. Bioactive Device to Reduce Postoperative Pain and Regenerate Bone. Sonny Bal, Mohamed N. Rahaman, Yue-Wern Huang, and Wei Xiao. (Invention Disclosure No. 18UMC010) · 2020. Smart On-Mask Sensor for Real-Time Detection of Respiratory Disease Causative Viruses Including Influenza and SARS-CoV-2. Chenglin Wu, Donghyun Kim, Yue-Wern Huang, Yang Wang, and Yanxiao Li. (Invention Disclosure) · 2020. Automatic and Rapid Detection and Tracing Influenza and SARS-CoV-2 viruses. Chenglin Wu, Yue-Wern Huang, Donghyun Kim, Cheng Wang, Yang, Wang, Xiangyang Dong. (Invention Disclosure No. 21MST007) (Provision patenting) FUNDING
AGENCIES · U.S. NIH · U.S. NSF · U.S. Army · U.S. EPA Region 7 · U.S. Fish and Wildlife Service · U.S. Geological Survey (USGS) · Missouri Department of Natural Resources · Missouri Water Resource Research Center · Missouri Department of Conservation · Saint Louis Zoo · The Doe Run Company (lead mining) · UM-System Research Board REFEREED PUBLICATIONS 2022. Betty Revon Liu, Shiow-Her Chiou, Yue-Wern Huang, and Han-Jung Lee. Bio-membrane internalization mechanisms of arginine-rich cell-penetrating peptides in various species. MDPI Membranes, 12, 88. https://doi.org/10.3390/membranes12010088. PDF 2022. Xuesong Liu, Jianmin Wang, and Yue-Wern Huang. Understanding the role of nano-TiO2 on the toxicity of Pb on C. dubia through modeling – is it additive or synergistic? Frontiers of Environmental Science and Engineering, 16(5): 59-70. PDF 2021. Natalie Holl, Han-Jung Lee, and Yue-Wern Huang. Evolutionary timeline of genetic delivery and gene therapy. Current Gene Therapy, 21(2):89-111. PDF 2021. Yanxiao Li, Zhekun Peng, Natalie J. Holl, Md. Rifat Hassan, John M. Pappas, Congjie Wei, Omid Hoseini Izadi, Yang Wang, Xiangyang Dong, Cheng Wang, Yue-Wern Huang, DongHyun Kim, Chenglin Wu. MXene-graphene field effect transistor sensing influenza virus and SARS-CoV-2. ACS Omega, 6(10):6643-6653. PDF 2021. Xuesong Liu, Jianmin Wang, and Yue-Wern Huang. Quantifying the effect of nano-TiO2 on the toxicity of lead on C. dubia using a two-compartment modeling approach. Chemosphere, 263:127958; doi:10.1016/j.chemosphere.2020.127958. PDF 2021. Mallikarjuna Korivi, Yue-Wern Huang, and Betty R. Liu. Cell-penetrating peptides as a potential drug delivery system for effective treatment of diabetes. Current Pharmaceutical Design, 27(6): 816-825. 2020.
Larry M. Tolliver, Natalie J. Holl, Fang Yao Stephen Hou, Han-Jung Lee,
Melissa H. Cambre, and Yue-Wern Huang. Differential cytotoxicity induced by transition
metal oxide nanoparticles is a function of cell killing and suppression of
cell proliferation. MDPI International Journal of Molecular Sciences, 21,
1731; doi:10.3390/ijms21051731. PDF 2020.
Melissa H. Cambre, Natalie J. Holl, Bolin Wang,
Lucas Harper, Han-Jung Lee, Charles Chusuei, Ethan
T. Williams, Jerry D. Argo, Raja Ram Pandey, Fang Yao Stephen Hou, and Yue-Wern Huang. Cytotoxicity of NiO and Ni(OH)2
nanoparticles is mediated by oxidative stress-induced cell death and
suppression of cell proliferation. MDPI International Journal of Molecular
Sciences, 21, 2355; doi:10.3390/ijms21072355. PDF 2020.
Sahitya Injamuri, Mohamed Rahaman,
Youqu Shen, and Yue-Wern Huang. Relaxin enhances bone regeneration with BMP-2
loaded hydroxyapatite microspheres. Journal of Biomedical Materials Research
Part A, doi: 10.1002/jbm.a.36897.
PDF 2020. Yang Wang, Guang Xu, and Yue-Wern Huang. Modeling the load of SARS-CoV-2 virus in human expelled particles during coughing and speaking. PLoS ONE, 15(10): e0241539. https://doi.org/10.1371/journal.pone.0241539. PDF 2020. Krishna C. R. Kolan, Yue-Wern Huang, Julie Semon, Ming C. Leu. 3D-printed biomimetic bioactive glass scaffolds for bone regeneration in rat calvarial defects. International Journal of Bioprinting, 6(2):274. doi:10.18063/ijb.v6i2.274. PDF 2020. Noland Ferral,
Nikki Gomez, Kyara Holloway, Haley Neeter, Megan Fairfield, Catherine Pollman,
Yue-Wern Huang, and Chen Hou. The
extremely low energy cost of biosynthesis in a Holometabolous insect species larvae.
Journal of Insect Physiology, 120 (2020) 103988. PDF 2019. Xuesong Liu, Jiamin Wang, Yue-Wern Huang, and Tao Kong. Algae (Raphidocelis) reduce combined toxicity of nano-TiO2 and lead on C. Dubia. Science of the Total Environment, 686: 246-253. PDF 2019. Han-Jung Lee, Yue-Wern Huang, Shiow-Her
Chiou, Robert S. Aronstam. Polyhistidine
facilitates direct membrane translocation of cell-penetrating peptides into
cells. Scientific Reports, 9:9398; doi.org/10.1038/s41598-019-45830-8. PDF 2019.
Han-Jung lee, Yue-Wern Huang, and
Robert Aronstam. Intracellular delivery of nanoparticles mediated by
lactoferricin cell-penetrating peptides in an endocytic
pathway. Journal of Nanoscience and Nanotechnology. 19(2):613-621; doi: 10.1166/jnn.2019.15751. PDF 2017. Yue-Wern Huang, Melissa Cambre, and Han-Jung Lee. The toxicity of nanoparticles depends on multiple molecular and physicochemical mechanisms. International Journal of Molecular Sciences 18, 2702; doi:10.3390/ijms18122702. PDF 2017.
Tunyaboon Laemthong, Hannah H. Kim, Kelly Dunlap, Caitlin Brocker,
Dipak Barua, Daniel Forciniti, Yue-Wern
Huang, and Sutapa Barua. Bioresponsive polymer
coating on targeted drug nanorods. IOP Nanotechnology, 28(4):045601. PDF 2017.
Betty R. Liu, Yue-Wern Huang, Mallikarjuna Korivi, Shih-Yen
Lo, Robert S.
Aronstam, and Han-Jung Lee. The primary
mechanism of cellular internalization for a short cell-penetrating peptide as
a nano-scale delivery system. Current Pharmaceutical Biotechnology
18(7):569-584. PDF 2017. Hsiu-Jen Wang, Yue-Wern Huang, Shakila Tobwala, Robert Aronstam, and Nuran Ercal. The role of N-acetylcysteine amide in defending primary human retinal pigment epithelial cells against tert-butyl hydroperoxide-induced oxidative stress. Free Radicals and Antioxidants, 7:172-177. PDF 2016. Kaushalya Amunugama, Lihong Jiao, Kathryn Koerperich, Yue-wern Huang, Paul Nam, and Chen Hou. Cellular oxidative damage is more sensitive to biosynthetic rate than to metabolic rate: Test the theory on hornworm (Manduca sexta larva). Experimental Gerontology, 82:73-80. PDF 2016. Betty R. Liu, Yue-Wern Huang, Robert S. Aronstam, and Han-Jung Lee. Identification of a short cell-penetrating peptide from bovine lactoferricin for intracellular delivery of DNA in human cells. PLOS ONE, 4:11(3):e0150439. doi: 10.1371/journal.pone.0150439. PDF 2015. Betty R. Liu, Yue-Wern Huang, Robert S. Aronstam,
and Han-Jung Lee. Comparative
Mechanisms of Protein Transduction Mediated by Cell-Penetrating Peptides in
Prokaryotes. International Journal of Molecular Sciences.
Journal of Membrane Biology. doi:10.1007/s00232-015-9777-x. PDF 2015. Yue-Wern Huang, Han-Jung Lee, Larry M. Tolliver, and Robert Aronstam. Delivery of nucleic acids and nanomaterials by cell-penetrating peptides: opportunities and challenges. BioMed Research International. Special Issue “Advances in Gene Delivery Systems”, volume 2015, article ID 834079, 16 pages. PDF 2015. Betty R. Liu, Hwei-Hsien Chen, Ming-Huan Chan, Yue-Wern Huang, Robert S. Aronstam, and Han-Jung Lee. Three arginine-rich cell-penetrating peptides facilitate cellular internalization of red-emitting quantum dots. Journal of Nanoscience and Nanotechnology 15(3):2067-2078. PDF 2014. Microsugar Chang, Yue-Wern Huang, Robert S. Aronstam, and Han-Jung Lee. Cellular delivery of noncovalently-associated macromolecules by cell-penetrating peptides. Current Pharmaceutical Biotechnology, 15:267-275. PDF 2013. Charles C. Chusuei, Chi-Heng Wu, Shravan Mallavarapu, Jeffrey G. Winiarz, Jong-Sik Moon, Robert S. Aronstam, and Yue-Wern Huang. Cytotoxicity in the age of nano: cell toxicity reflects certain physiochemical properties of fourth period of metal oxide nanoparticles. Chemico-Biological Interactions, 206:319-326. Text PDF; Suppl. PDF. 2013. Betty R. Liu, Jeffrey G. Winiarz, Jong-Sik
Moon, Shih-Yen Lo, Yue-Wern Huang,
Robert S. Aronstam, Han-Jung Lee. Synthesis, characterization and applications of carboxylated and polyethylene-glycolated
bifunctionalized InP/ZnS
quantum dots in cellular internalization mediated by cell-penetrating peptides. Colloids
and Surfaces B: Biointerfaces 111:162-170. (Y.
H. and H. L. are corresponding authors.) PDF 2013. Betty Revon Liu, Shih-Yen Lo, Chia-Chin Liu, Chia-Lin Chyan, Yue-Wern Huang, Robert S. Aronstam, Han-Jung Lee. Endocytic trafficking of quantum dots delivered by Pas nona-arginine cell-penetrating peptides in cells. doi:10.1371/journal.pone.0067100. PLOS ONE 8(6): e67100. PDF 2013. Betty Revon Liu, Shih-Yen Lo, Chia-Chin Liu, Chia-Lin Chyan, Yue-Wern Huang, Robert S. Aronstam, Han-Jung Lee. Intracellular delivery of nanoparticles and DNAs by IR9 cell-penetrating peptides. doi:10.1371/journal.pone.0064205. PLOS ONE 8(5): e64205. PDF 2013. Ji-Sing Liou, Betty Revon Liu, Yung-Hen Che, Yue-Wern Huang, Han-Jung Lee. Delivery of nucleic acids, proteins, and nanoparticles by arginine-rich cell-penetrating peptides in rotifers. Marine Biotechnology doi:10.1007/s10126-013-9509-0. PDF 2013. Betty Revon Liu, Yue-Wern Huang, Huey-Jenn Chiang, and Han-Jung Lee. Mechanistic studies of intracellular delivery of proteins by cell-penetrating peptides in cyanobacteria. BMC Microbiology 13:57. DOI:10.1186/1471-2180-13-57. PDF 2013. Betty Revon Liu, Huey-Jenn Chiang, Yue-Wern Huang, Ming-Huan Chan, Hwei-Hsien Chen and Han-Jung Lee. Cellular internalization of quantum dots mediated by cell-penetrating peptides. Pharmaceutical Nanotechnology 1(2): 151-161. PDF 2013. Ninu Madria, Nanditha Nair, Avinash Vadapali, Yue-Wern Huang, Simon Jones, and V. Prakash Reddy. Ionic liquid electrolytes for lithium batteries: Synthesis, electrochemical, and cytotoxicity studies. J. of Power Sources 234:277-284. PDF 2013. Hsiu-Jen Wang, Alexis Martin, Po-Kuan, Rhett Reichard, Adam L. Martin, Yue-Wern Huang, Ming-Huan Chan, and Robert S. Aronstam. Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling. J. of Biomedical Science 20:11. DOI:10.1186/1423-0127-20-11. PDF 2013. Tso-Hao Tang , Chiung-Tan
Chang , Hsiu-Jen Wang, Joshua D. Erickson, Rhett A. Reichard, Alexis G.
Martin, Erica K. Shannon, Adam L. Martin, Yue-wern Huang, and Robert S. Aronstam. Oxidative stress disruption of receptor-mediated calcium
signaling mechanisms. doi:10.1186/1423-0127-20-48.
Journal of Biomedical Science 20:48. (Highly
accessed) PDF 2013. Betty R. Liu, Yue-Wern Huang, Huey-Jenn Chiang, and Han-Jung Lee. Primary effectors in the mechanisms of transmembrane delivery of arginine-rich cell-penetrating peptides. Advanced Studies in Biology 5(1):11-25. PDF 2012. Ji-Sing Liou, Betty Revon Liu, Adam Martin, Yue-Wern Huang, Huey-Jenn Chiang, and Han-Jung Lee. Protein transduction in human cells is enhanced by cell-penetrating peptides fused with an endosomolytic HA2 sequence. Peptides 37:273-284. (Y. H. and H. L. are corresponding authors.) PDF 2011. Cheng-Yi Lee, Jheng-Fong Li, Ji-Sing Liou, Yuh-Chyang Chang, Yue-Wern Huang, and Han-Jung Lee. A gene delivery system mediated by both a cell-penetrating peptide and a PiggBac transposase into human cells. Biomaterials 32:6264-6276. PDF 2011. Betty Revon Liu, Yue-Wern Huang, Jeffrey G. Winiarz, Huey-Jenn Chiang, Han-Jung Lee. Intracellular delivery of quantum dots mediated by histidine- and arginine-rich HR9 cell-penetrating peptides through the direct membrane translocation mechanism. Biomaterials 32:3520-3537. PDF 2010. Yue-Wern Huang, Chi-heng Wu, and Robert S. Aronstam. Current understanding on toxicity of transition metal oxides: recent insights from in vitro studies. Materials. Special Issue Metal Nanoparticles 3:4842-4859. DOI:10.3390/ma3104842. PDF 2010. Yi Xu, Betty Revon Liu, Han-Jung Lee, Katie B. Shannon, Jeffrey G. Winiarz, Tien-Chun Wang, Huey-Jenn Chiang, and Yue-Wern Huang. Nona-arginine facilitates delivery of quantum dots into cells via multiple pathways. Journal of Biomedicine and Biotechnology 2010:11. DOI:10.1155/2010/948543. PDF 2010.
Hsiu-Jen Wang, Tso-hao Tang, Anna C. Growcock,
Jennifer O’Hara, Adam Martin, Yue-Wern
Huang, and Robert S. Aronstam. Zinc oxide nanoparticle disruption of
store-operated calcium entry in a muscarinic receptor signaling pathway.
Toxicology in Vitro 24:1953-1961. PDF 2010. Betty R. Liu, Yue-Wern Huang, Huey-Jenn Chiang, Han-Jung Lee. Cell-penetrating peptide-functionized quantum dots for intracellular delivery. Journal of Nanoscience and Nanotechnology 10:7897-7905. PDF 2010. Betty R. Liu, Jheng-Fong Li, Shu-Wan Lu, Han-Jung Lee, Katie B. Shannon, Yue-Wern Huang, and Robert S. Aronstam. Cellular Internalization of quantum dots noncovalently conjugated with arginine-rich intracellular delivery peptides. Journal of Nanoscience and Nanotechnology 10:6534-6543. PDF 2010. Chuan-Chin Huang, Robert S. Aronstam, Da-Ren Chen, and Yue-Wern Huang. Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles. Toxicology in Vitro 24:45-55. DOI:10.1016/j.tiv.2009.09.007. (13 September 2009) PDF 2010. Chuan-Chin Huang, Yi Xu, Paul Nam, Jeff Briggler, Mike McKee, and Yue-Wern Huang. Heavy metals, hematology, and serum chemistry in adult hellbenders. (Cryptobranchus alleganiensis). Environmental Toxicology and Chemistry 29:1132-1137. PDF 2009. Weisheng Lin, Yi Xu, Chuan-Chin Huang, Yinfa Ma, Katie B. Shannon, Da-Ren Chen, and Yue-Wern Huang. Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cells. Journal of Nanoparticle Research 11:25-39. DOI:10.1007/s11051-008-9419-7. (10 June 2008) PDF 2009. Rong Shi, Chuan-Chin Huang, Robert S. Aronstam, Nuran Ercal, Adam Martin, and Yue-Wern Huang. N-acetylcysteine amide protects H9c2 cardiomyocytes from doxorubicin-induced toxicity. BMC Pharmacology 2009, 9:7. DOI:10.1186/1471-2210-9-7. (15 April 2009) (article classified as “Highly accessed” (>1750 by July 2009). PDF 2008. Weisheng Lin, Isaac Stayton, Yue-Wern Huang, Xiao-Dong Zhou, and Yinfa Ma. Cytotoxicity and cell membrane depolarization induced by aluminum oxide nanoparticles in human lung epithelial cells A549. Toxicological and Environmental Chemistry 90:983-996. DOI:10.1080/02772240701802559. PDF 2008. Loretta Hunter, Gary Gadbury, and Yue-Wern Huang. Atrazine exposure and breast cancer incidence: an ecologic study of Missouri counties. Toxicological and Environmental Chemistry 90:367-376. PDF 2007. Yue-Wern Huang, David J. Hoffman, and William H. Karasov. Oxidative stress induced in PCB-exposed northern leopard frogs, Rana pipiens. Journal of Toxicology and Environmental Health Part A 70:676-681. PDF 2007.
Mauricio Solis, Chihchin Liu, Janet Bandeff, Paul Nam, Dev Niyogi, and Yue-Wern Huang. Occurrence
of organic chemicals in two rivers inhabited by Ozark hellbenders (Cryptobranchus alleganiensis bishopi). Archives of Environmental Contamination and
Toxicology 53:426-434. PDF 2007. Yue-Wern Huang, Jacob R. Phillips,
and Loretta Hunter. Human exposure to
medical, dietary, and environmental estrogens. Toxicological and Environmental Chemistry
89:141-160. PDF
2007. Mauricio E. Solis and Yue-Wern Huang. Hematology and serum chemistry of Ozark and Eastern hellbenders (Cryptobranchus alleganiensis). Herpetologica 63:285-292. PDF 2006. Weisheng Lin, Yue-Wern Huang, Xiao-Dong Zhou, and
Yinfa Ma. In Vitro toxicity of silica nanoparticles in human
lung cancer cells. Toxicology and
Applied Pharmacology 217: 252-259. PDF 2006. Weisheng Lin, Yue-Wern Huang, Xiao-Dong Zhou, and Yinfa Ma. Toxicity of cerium oxide nanoparticles in human lung cancer cells. International Journal of Toxicology 25: 451-457. (Best Paper Award by the International Journal of Toxicology and the 28th Annual Meeting of the American College of Toxicology in Charlotte, NC.) PDF 2005. Yue-Wern Huang, Jason Matthews, Kirsten Fertuck, and Tim Zacharewski. Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Environmental Toxicology and Chemistry 24: 2002-2009. PDF 2004. Junnan Chen, Yue-Wern Huang, Guanshu Liu, Zahra Afrasiabi, Ekkehard Sinn, and Yinfa Ma. The anticancer activity and the mechanism study of 1,2 naphthoquinone thiosemicarbazone and its metal derivatives against MCF-7 human breast cancer cells. Toxicology and Applied Pharmacology 197:40-48. PDF 2004. Nord L. Gale, Craig D. Adams, Bobby G. Wixson, Keith A. Loftin, and Yue-Wern Huang. Lead, zinc, copper, and cadmium in fish and river sediments from the Big River and Flat River Creek of Missouri Old Lead Belt. Environmental Geochemistry and Health 26:37-49. PDF 2003. Yue-Wern Huang, Jason Elrod, and Dirac Twidwell. Occurrence and effects of EDCs in the environment. In Endocrine Disrupting Compounds in the Environment, edited by C. Adams and A. Bhandari. ASCE Hazardous, Toxic, and Radioactive Waste Management (HTRWM) Practice Periodical 7 (4):241-252. American Society of Civil Engineering. PDF 2002. Jason B. Matthews, Trine Celius, Kirsten C. Fertuck, Yue-Wern Huang, Cora Fong, and Tim R. Zacharewski. Ability of several natural and synthetic estrogenic chemicals to induce gene expression mediated by estrogen receptors from several vertebrate species. Journal of Steroid Biochemistry and Molecular Biology 82:181-194. PDF 2002. Nord L. Gale, Craig D. Adams, Bobby G. Wixson, Keith A. Loftin, and Yue-Wern Huang. Lead levels in fish and river sediments in the Old Lead Belt of Missouri. Environmental Science and Technology 36:4262-4268. PDF 2001. Yue-Wern Huang, John J. Stegeman, Bruce R. Woodin, and William H. Karasov. Immunohistochemical localization of cytochrome P450-associated monooxygenases induced by 3,3',4,4',5-pentachlorobiphenyl in multiple organs of northern leopard frog, Rana pipiens. Environmental Toxicology and Chemistry 20:191-197. PDF 2000. Yue-Wern Huang and William H. Karasov. Oral bioavailability, distribution, and elimination of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in northern leopard frogs, Rana pipiens. Environmental Toxicology and Chemistry 19:1788-1794. PDF 1999. Yue-Wern Huang, William H. Karasov, Kathy A. Patnode, and Colin R. Jefcoate. Exposure of northern leopard frogs in the Green Bay ecosystem to PCBs, PCDDs, and PCDFs is measured by direct chemistry but not hepatic EROD activity. Environmental Toxicology and Chemistry 18:2123-2130. PDF 1998. Yue-Wern Huang, Mark. J. Melancon, Robin. E. Jung, and William. H. Karasov. Induction of cytochrome P450-associated monooxygenases in northern leopard frogs, Rana pipiens, by 3,3',4,4',5-Pentachlorobiphenyl (PCB 126). Environmental Toxicology and Chemistry 17:1564-1569. PDF BOOK CHAPTERS 2021. Natalie J. Holl, Moumita Dey, Yue-Wern Huang, Shiow-Her Chiou, and Han-Jung Lee. Chapter 9: Lactoferricin-Derived L5a Cell-Penetrating Peptide for Delivery of DNA into Cells. In Methods in Molecular Biology. Kumaran Narayanan (ed.). Humana Press, New Jersey, pp 113-121. PDF 2019. Betty Revon Liu, Yue-Wern Huang, and Han-Jung Lee. Chapter 4: Efficient DNA Transfection in Protists Mediated by Cell-Penetrating Peptide. In Gene Delivery: Methods and Applications. Vanessa Zimmer (ed.). Nova Science Publisher, Hauppauge, New York, pp 165-185. PDF 2019. Betty Revon Liu, Yue-Wern Huang, and Han-Jung Lee. Chapter 4: Hypotoxic Fluorescent Nanoparticles Delivery by Cell-Penetrating Peptides in Multiple Organisms: from Prokaryotes to Mammalians Cells. In: Bioengineering. Eduardo Jacob-Lopes (ed.); IntechOpen, London, UK. (In press). PDF 2018. Yue-Wern Huang and Han-Jung Lee. Cell-Penetrating Peptides for Medical Theranostics and Targeted Drug Delivery. In: Peptide Applications in Biomedicine, Biotechnology and Bioengineering. Sotirios Koutsopoulos (ed.) Elsevier Press. pp 359-370. 2018. Yue-Wern Huang and Sutapa Barua. Chapter 6: Oral Drug Delivery Systems for Gastrointestinal Cancer Therapy. In: Cancer Therapeutics and Imaging. Kaushal Rege (ed.); World Scientific Publishing. pp 187-218. PDF 2015. Charles C. Chusuei, Chi-Heng Wu, Shravan Mallavarapu, Fang Yao Stephen Hou, Chen-Ming Hsu, Robert S. Aronstam and Yue-wern Huang. Chapter 8: Review: Physicochemical Structure Effects on Metal Oxide Nanoparticulate Cytotoxicity. In: Recent Progress in Surface and Colloids Chemistry with Biological Applications. Editors Wang, C; Hauserman, B. ACS Symposium Series, Vol.1215. American Chemistry Society, Washington DC, pp 137-155. PDF 2015. Betty R. Liu, Yue-Wern Huang, Robert S. Aronstam, and Han-Jung Lee. Chapter 8: Cell-Penetrating Peptide-Mediated Protein Uptake in Cyanobacteria. In Cyanobacteria: Ecological Importance, Biotechnological Uses and Risk Assessment. Douglas Davison (ed.): Nova Science Publishers, Hauppauge, New York, pp 171-181. PDF 2013. Betty Revon Liu, Ming-Huan Chan, Hwei-Hsien Chen, Shih-Yen Lo, Yue-Wern Huang, and Han-Jung Lee. Chapter 3: Effects of surface charge and particle size of cell-penetrating peptide/nanoparticle complexes on cellular internalization. In: Cell Membrane, Mandraccia L and Slavin G. (eds.); Nova Science Publisher, Hauppauge, New York, pp 43-56. PDF 2013. Betty R. Liu, Ming-Huan Chan, Hwei-Hsien Chen, Yue-Wern Huang, Han-Jung Lee. Chapter 4: Protein Transduction in Human Cells Mediated by Arginine-rich Cell-penetrating Peptides in Mixed Covalent and Noncovalent Manners. In: Macromolecular Chemistry: New Research. Gartner, V. (ed.): Nova Science Publisher, Hauppauge, New York, pp 69-82. 2013. Yue-Wern Huang, Han-Jung Lee, Betty Revon Liu, Chi-Heng Wu. Chapter 23: Cellular Internalization of Quantum Dots. In Cellular and Subcelluar Nanotechnology: Methods and Protocols. Weissig, V.; Elbayoumi, T.; Olsen, M. (eds.): Humana press, New York, pp. 249-259. PDF 2010. Betty Revon Liu, Ching-Yi Chen, Rong-Long Chen, Huey-Jenn Chiang, Yue-Wern Huang, and Han-Jung Lee. Chapter 8: Macropinocytosis: Possible Mechanisms of Cellular Entry of Arginine-rich Intracellular Delivery Peptides. In Endocytosis: Structural Components, Functions and Pathway. Dowler, B.C. (eds.): Nova Science Publishers, Hauppauge, New York, pp. 177–190. 2009. Yue-Wern Huang, Dev K. Niyogi, Paul K. Nam, and Janet M. Bandeff. Chapter 10: Livestock Hormones in Aquatic Ecosystems. In Veterinary Pharmaceuticals in the Environment, ACS Symposium Series 1018; Coats, J.R.; Henderson, K.L. (eds.); Oxford University Press, New York, pp. 135–152. PDF MANUSCRIPTS SUBMITTED OR IN PREPARATION 2020. Youqu
Shen, Mohamed Rahaman, and Yue-Wern Huang. Evaluation of open hollow hydroxyapatite microsphere
on bone regeneration in rat calvarial defects. (Submitted to MDPI Functional
Biomaterials) 2020. Xuesong Liu, Jianmin Wang, and Yue-Wern Huang. Algae (Raphidocelis) and pH on the combined toxicity of nano-TiO2 and arsenic on C. dubia: the view of arsenate uptake and depuration. (Submitted to Chemosphere.) 2020. Xuesong Liu, Jianmin Wang, and Yue-Wern Huang. Quantifying the effect of nano-TiO2 on the toxicity of lead on C. dubia using a two compartment modeling approach. (In prep.) 2020. Betty Revon Liu, Yue-Wern Huang, and Han-Jung Lee. Chapter XX: Efficient DNA Transfection in Protists Mediated by Cell-Penetrating Peptide. In Gene Delivery: Methods and Applications. Nova Science Publisher, Hauppauge, New York, pp xx-yy. (In press) INVITED PRESENTATIONS 2018, June 5. National Cheng Chi University. Title: Inspired by the Nature. Taipei, Taiwan. 2018, March 10. Missouri S&T, Department of Chemical Engineering. Delivery of Biologically Active Molecules for Biomedical Research and Application: Uptake, Efficacy and Toxicity. Rolla, MO, USA. 2017, November 12. Oklahoma State University, Department of Integrative Biology. Title: From Ecology to Nanobiotechnology: A Journey of Life Science Research. Stillwater, OK, USA. 2016, May 25. National Cheng Chi University. Title: A Journey of Environmental Protection: Putting it in Social and Education Context. Taipei, Taiwan. 2015, Sept. 28. University of Missouri-Columbia. Title: Properties of Engineered Nanoparticles Influence Nanodelivery and Nanotoxicity. Columbia, MO, USA. 2014, May 26. National Taiwan Normal University. Title: Biology and Beyond. Taipei, Taiwan. 2014, May 23. National Taiwan Normal University. Frontiers in Biopharmaceuticals Conference. Title: Materials for Biomedical Applications. Taipei, Taiwan. 2013, July 4, 2013. Academia Sinica Institute of Atomic and Molecular Science. Title: Cytotoxicity is a Function of Multiple Physical and Chemical Properties of Nanomaterials: Implications for Design of Safer Nanomaterials. Taipei, Taiwan. 2012, August 7. US EPA. Cytotoxicity of Transition Metal Oxide Nanoparticles Depends on Certain Physicochemical Properties. Research Triangle Park, NC, USA. 2011, Nov. 29. University of Missouri-Columbia. Presentation title: TBD. 2011, July 5. Academia Sinica. Presentation title: Cell-Penetrating Peptide Mediated Delivery of Nanomaterials: Routes of Cell Entry. 2011, June 28. National Cheng Kung University. Presentation title: Cell-Penetrating Peptide Mediated Delivery of Nanomaterials: Routes of Cell Entry. Tainan, Taiwan. 2011, June 24. National Dong Hwa University. Presentation title: Non-metal vs. Metal Oxide Nanoparticles: Roles in ROS-Induced Toxicity. Hualien, Taiwan. 2011, June 22. National Taiwan Normal University. Presentation title: Cell-Penetrating Peptide Mediated Delivery of Nanomaterials: Routes of Cell Entry. Taipei, Taiwan. 2011, February 24. Missouri S&T Department of Chemical and Biological Engineering. Presentation title: Nanotechnology. Rolla, MO. USA. 2010, June 1. Tzu Chi University Department of Pharmacology and Toxicology. Presentation title: Cytotoxicity of Transitional Metal Oxide Nanoparticles in the 4th Period of the Periodic Table. Hualien, Taiwan. 2010, May 24. National Taiwan University College of Public Health. Presentation title: Metal Oxides Influence Cellular Homeostasis via Multiple Interconnected Signaling Pathways. Taipei, Taiwan. 2009, November 14. Midwest Chinese American Science and Technology Association. Presentation title: A Novel System to Deliver and Monitor Biologically Active Molecules. St. Louis, MO, USA. 2009, June 2. National Ilan University. Presentation title: “Nano-sized Metal Oxides Induce Oxidative Stress and Alter Calcium Homeostasis in Human Bronchial Epithelial Cells (BEAS-2B)”. Ilan, Taiwan. 2009, May 1. New York University Nelson Institute of Environmental Medicine. Presentation title: “Nanotechnology: a doubled edged sword”, Tuxedo, New York, USA. 2009, March 9. University of Colorado-Denver Department of Biology. Presentation title: “Nanotechnology: a doubled edged sword”. Denver, Colorado, USA. 2007, August 23. National Cheng Kung University Medical College. Presentation title: “Nanomaterial toxicity and mechanisms”. Tainan, Taiwan. 2007, August 27. Tzu-Chi University Department of Pharmacology and Toxicology. Presentation title: “Nanomaterial toxicity and mechanisms”. Hualien, Taiwan. 2007, March 25-29. Invited presentation, 233rd American Chemical Society National Meeting. “Human and wildlife exposure to hormones from livestock”. Chicago, IL, USA. 2006, September 26. Invited seminar, Clemson University. “Endocrine disruption and nanoparticle toxicity: an interdisciplinary approach”. Clemson, South Carolina, USA. 2006, February 1-3. Invited presentation, Missouri Natural Resources Conference. “General health, reproductive hormones, and habitat water quality of Ozark hellbenders, Cryptobranchus alleganiensis Bishopi.” Lake of the Ozarks, Missouri, USA. 2005, December 19-21. Invited speaker, Advancement of Biological Research Symposium. A joint annual conference between Taiwan and China. “Nanoparticle toxicity screening.” Taipei, Taiwan. 2004, March 3-5. Plenary speaker, Annual SETAC Ozark-Prairie Chapter Meeting. A joint meeting with the SETAC Midwest Chapter. “Searching for possible causes of the population decline in Ozark hellbenders.” La Crosse, Wisconsin, USA. 2003, January 31. Division of Science, Truman State University. “Point source and nonpoint source endocrine disruption studies in the environment.” Kirksville, Missouri, USA. 2002, November 14. Invited seminar, Department of Wildlife and
Fisheries Sciences, Texas A & M University. “Endocrine Disruptor screening.” College Station, Texas, USA. 2002, June 12. Department of Microbiology, Soochow University, Taipei, Taiwan. 2002, June 13. Department of Life Sciences, Tzu-Chi University, Hualien, Taiwan. 2002, June 14. Department of Life Sciences, National Dong Hwa Univesity, Hualien, Taiwan. 2002, June 18. Division of
Environmental Health and Occupational Medicine, National Health Research
Institutes, Kaohsiung, Taiwan. 2002, June 27. Department of Biology, National Taiwan Normal University, Taipei, Taiwan. 2001, February. 1. USGS in
Columbia. “Exposure of northern
leopard frogs to PCB 126, an aryl hydrocarbon receptor agonist: direct
chemistry, biochemical Markers, and toxicokinetics.” Columbia, Missouri, USA. 2001, January. 19. Department of Biology, Southwest Missouri State University. In vitro and in vivo bioassays for investigating endocrine disruption in Xenopus laevis. Springfield, Missouri, USA. 1999, December. National Taiwan Normal University. “Amphibian exposure to chlorinated hydrocarbons.” Taipei, Taiwan. 1999, December. National Central University. “Amphibian exposure to environmental estrogenic chemicals.” Chong-Li, Taiwan. MEDIA
EXPOSURE 1. Jan. 17, 2014. Wissenschaft Aktuell (Current Science). Toxisch: Wie gefährlich sind Nanoteilchen aus Metalloxiden? 2. May-June, 2008. “The Hellbender” in Nick Baker’s Weird Creature. BBC. 3. June, 2005. Wildlife Conservation Magazine. “The hellbender needs help”, pages 51-54. 4. Feb. 12, 2005. 30-minute broadcast of hellbender research on Public Broadcasting System (PBS). Film provided by MDC. 5. Oct. 25, 2004. Columbia Daily Tribune, “Team of biologist hell-bent on saving fading salamanders”, page 2A. 6. Oct. 24, 2004. ST. Louis Post-Dispatch, “Scientists seek to save once-thriving hellbender” Front page, A12-A13. The story was later picked up by Associated Press, Kansas City Star, and Kansas City television station KCTV-5. 7. MDC filmed the hellbender research. The video was broadcast in Missouri Outdoors TV program several times. 8. July 23, 2003. Star-Crawford Mirror in Steelville. “UMR Biologist Tries to Save the Ozark Hellbender” 9. June 18, 2003. Sullivan Independent News. “UMR Biologist Tries To Save the Ozark Hellbender” 10. June 17, 2003. Park Hills Daily Journal. “Researchers looking to save Ozark salamanders from extinction” 11. June 17, 2003. St. Louis Post-Dispatch. “Scientists Study Decline of Local Salamander – the Ozark Hellbenders” 12. June 16, 2003. Camdenton Lake Sun Leader. “On a mission for Ozark salamanders” 13. June 16, 2003. Cape Girardeau Southeast Missourian. “Researchers looking to save Ozark salamanders” 14. June 16, 2003. Moberly Monitor Index. “Researchers look to save salamanders” 15. June 16, 2003. Parksville Daily Express & News. “Researchers Fight To Save Ozark Salamanders From Extinction” 16. June 16, 2003. News-Leader in Springfield. “Hellbenders” 17. June 15, 2003. The Associate Press State & Local Wire (in Ganisville, MO). “Researchers looking to save Ozark salamanders from extinction” 18. May 30, 2003. UMR W3. “Huang’s Research Could Save the Hellbender” 19. May 2003. Rolla Channel 16. Hellbender Research. 20. May 12, 2003. UMR eConnection. “Biologist Works to Save Hellbenders” 21. May 11, 2003. Rolla Daily News. “UMR Biologist Works To Save Ozark Hellbender” 22. Dec. 2002. UMR Alumni Magazine. “Saving the Hellbender.”
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was last updated 07/29/03